The Cramps - Human Fly [WORK]

The song "Human Fly" by The Cramps centers around the idea of being different from the crowd, and pushing boundaries. The lyrics and distinct sound evoke a sense of rebellion and individualism; the character in this song is a human fly, someone not bound by traditional conventions but embracing their own unique style and identity. The song also touches on internal struggles; the character has 96 tears and 96 eyes, perhaps indicating a heightened emotional sensitivity, and their garbage brain suggests a tendency towards mental instability. Ultimately, the song encourages listeners to accept their differences, be proud of their individuality, and to let their own spirit soar like a fly.

The Cramps - Human Fly

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Several studies have identified the human gene GIGYF2 (GRB10 Interacting GYF Protein 2) as a possible susceptibility locus for Parkinson disease. Evidence in some studies is consistent with an autosomal dominant mode of inheritance, with variable penetrance, but these results are not observed in other similar studies (see OMIM:607688). The GIGYF2 protein is thought to act cooperatively with GRB10 in the regulation of tyrosine kinase receptor signaling; it is a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. There is a single orthologous gene in Drosophila, Gyf, for which RNAi-targeting constructs and alleles caused by insertional mutagenesis have been generated. Dmel\Gyf is orthologous to a second similar gene in human, GIGYF1.

Parkinson disease (PD) is a neurodegenerative disease usually typified by slow onset in mid to late adulthood; there are also early-onset and juvenile forms of the disease. Symptoms worsen over time and include resting tremor, muscular rigidity, bradykinesia [abnormal slowness of movement], and postural instability [impaired balance and coordination]; additional symptoms may include postural abnormalities, dysautonomia [symptoms caused by malfunction of the autonomic nervous system], dystonic cramps, and dementia. Parkinson disease is the second-most common neurodegenerative disease (after Alzheimer disease), affecting approximately 1% of the population over 50 (Polymeropoulos et al., 1996, pubmed:8895469). [from OMIM:168600; 2013.07.23] 041b061a72